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PEGylated Mechano Growth Factor - PEG-MGF





Russianstar " Experiences with MGF and PEG MGF a complete guide.

This article will discuss the use of Mechano growth factor and clear up a few myths.

WHAT IS MGF?

Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue, Its called MGF as IGF-1Ec is a bit of a mouthful and harder to identify amongst the other igf variants.

What makes MGF special is its unique role in muscle growth.

MGF has the ability to cause wasted tissue to grow and improve itself by activating muscle stem cells and increasing the up regulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth.

MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-Ireceptor domain which then in turn increases protein synthesis turnover, and therefore can if used correctly improve muscle mass over time.

The liver produces 2 kinds of MGF splice variants of igf..

1) IGF-1Ec This is the first phase release igf splice variant and it appears to stimulate satellite cells into activation, This is the closest variant to synthetic MGF.

2) liver type IGF-IEa this is the secondary release of igf from the liver, and its far less anabolic.

MGF differs from the second variant IGF-IEa as it has a different peptide sequence which is responsible for replenishing the satellite cells in skeletal muscle, in other words it is more anabolic and longer acting than the systematic release of the second MGF liver variant.

So just think of MGF as a highly anabolic variant of igf. After you have trained, the IGF-I gene is spliced towards MGF then that causes hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as other important anabolic processes, including the above mentioned protein synthesis, and increased nitrogen retention.

In rats some studies have shown muscle mass increases of 20 percent from a single mgf injection.. somehow I think many of these studies are not accurate, however the potential is undeniable.

HOW TO USE MGF

Now when you train what happens to your muscles, they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant, The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die, that's the large and small of it.

As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair , If the cells are not repaired they die and your muscles get smaller and weaker.

The muscle The pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.

Now with synthetic injections of MGF you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. 200mcg bi laterally is the very best choice of dosing in muscles trained.

The only problem with MGF and this is the reason I don't like it, is that it has such a short half life, just a few minutes, between 5-7, and it needs to be used immediately post workout as it wont work if muscle tissue hasn't been damaged, that's why for me personally i think the best option is PEG MGF.

Nevertheless MGF has a huge role to play, and is administered to those with muscle wasting diseases and for those who are elderly and have lost muscle mass for good reason, it is EXTREMELY anabolic.

 

HOW TO USE PEG MGF

 

This is a very important section.

When using MGF that's pegylated that's the addition of Polyethylene glycol, its a non toxic additive that increased the half life of MGF from minutes to hours.

This means its uses and versatility make it a tremendous addition to a bodybuilders arsenal.

I have found it most effective as its effects are systematic, that means they have a whole body effect wherever muscle has been damaged or is diseased.

The next aspect we need to look at is how to make the most use of a long acting version of MGF.

When your muscle is damaged your body releases a pulse of an MGF splice variant as i outlined above, followed by a less anabolic longer acting version from the liver... So it seems a waste to inject MGF at this time as you will just blunt your body's own release, your not enhancing it.

So using PEG MGF on non workout days is actually the very best route, the muscle has been damaged, so there are plenty of receptors for MGF, the effects are systematic so all muscles will be helped to recover through increased nitrogen retention, protein turnover, and satellite cell activation. Recovery is just going to sky rocket.

Doing this means your increasing the length of your body's own mechanism for muscle repair and growth, your opening up the anabolic window.

NOW PLEASE TAKE CAREFUL NOTE.

Running PEG MGF in synergy with IGF is perfect but there are things you need to know.

If you dose them at the same time, as IGF has such strong receptor affinity, The effectiveness of MGF will just be wasted.

The best option and the very best choice I feel is this....

IGF DES on workout days Pre workout, or IGF1-LR3 this wont blunt your body's own MGF release from the liver, and whereas IGF1-LR3 has a more systematic effect and only a very small localized anabolic effect, DES on the other hand is very anabolic in a localized way, so bring up lagging muscle parts with DES, and then the following day Dose MGF at 200-400mcg subq to increase recovery and the mechanism for growth. Perfect synergy.

Over a 4 week run i noticed about 4lb increase with the PEG MGF and DES partnership. And roughly the same weight in fat loss, very impressive, some though have noted far greater increases in muscle mass.

If your on an AAS cycle there is no need for the addition of DES as IGF levels will already be elevated, then the addition of PEG MGF can take your recovery and gains to a new level.

STORAGE ETC

Dosing 3 times a week is best, and 1ml of BA water for every 2mg is optimal. Storage in the fridge for up to 6 months. Avoid exposure to heat or sunlight.

 

According to RS nice protocol of IGF DES and PEG MGF will be
IGF DES during workout 80mcg and above ( about 4X week)
PEG MGF next day of workout of day 200-400 mcg at 2 pm (about 3X week)

but for beginners
50mcg IGF DES and 200mcg PEG MGF is sufficient
My bro got nice results with these peptides
Gained about 8 pounds pure muscle mass in just 5 weeks

Current cycle
week 1-16 test e 500mg/week
week 1-14 deca 400mg/week

 

Quick summary: MGF is a splice variant of the IGF produced by a frame shift if the IGF gene. MGF increase the muscle stem cell count, so that more may fuse and become part of adult muscle cells. This is a process required for adult muscle cells to continue growing.

Why PEGylate MGF?

MGF exhibits local effects in skeletal muscle and without modification is not systemic (can’t travel through the body). The problem with synthetic MGF is that it is introduced IM and is water based so it goes into the blood stream. MGF is not stable in the blood stream for more than a matter of minutes. Biologically produced MGF is made locally and does not enter the bloodstream and is short acting so stability is not an issue. By PEGylating the MGF we can make synthetic MGF injected IM almost as efficient as local produced MGF. Clinically proven Advanced Pegylation, the technology of polyethylene glycol (PEG) conjugation, holds significant promise in maintaining effective plasma concentrations of systemically administered drugs. It does this by surrounding part of the peptide with a unique structure made of polyethylene glycol, which can be attached to a protein molecule. The result of a correct PEGylation is similar to the protective mechanism of a turtle shell. The polyethylene glycol groups protect the peptide but don’t surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein. This also provides a nice steric chamber for the peptide to reside in. So it’s a happy turtle

Neurological research has shown that utilizing PEGylated MGF resulted in a longer more stable acting version of the MGF peptide in serum/blood.

Bottom line

PEGylation can improve performance and dosing convenience of peptides, proteins, antibodies, oligonucleotides and many small molecules by optimizing pharmacokinetics, increasing bioavailability, and decreasing immunogenicity and dosing frequency. PEGylation also can increase therapeutic efficacy by enabling increased drug concentration, improved biodistribution, and longer dwell time at the site of action. As a result, therapeutic drug concentrations can be achieved with less frequent dosing—a significant benefit to patients who are taking injected drugs.

The PEG itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. PEG has demonstrated little toxicity, is eliminated intact by the kidneys or in the feces and lacks immunogenicity. The risk associated with current PEGylated drugs are due to the way the drug itself acts not the PEG. MGF, as it is being currently sold, is getting a bad rep from people due to the fact they feel that they are not seeing gains from it. Many people believe that the use of MGF in their cycles or protocols just flat out won't work, however, this is far from the truth.


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