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Nilevar


 

 

Pharmaceutical Name: Norethandrolone
Chemical structure: 17-alpha-ethyl-19-Nor-4-androstene-3-one,17b-ol
Chemical Formula: C20 H30 O2
Molecular Weight: 302.4558
Melting Point: 130-136 Celsius
Active life: 12-16 hours
Anabolic/Androgenic ratio (Range): 100-200/22-55



Norethandrolone is a moderately anabolic oral 17-alpha alkylated steroid. It was one of the first oral steroids available in the North America (1). It is a 19-nortestosterone steroid. For this reason its effects are often compared to those of deca durabolan, however this is a rather simplistic explanation.

Androgenic side effects are much more likely to occur with Norethandrolone than with most other nandrolones. As well, due to the fact that it is 17-alpha alkylated it converts to 17 alpha ethyl estradiol, a very active form of estradiol. This is likely to result in more severe estrogenic side effects for users in comparison to say nandrolone decanoate. For this reason use of ancillary compounds to try and prevent estrogen-related side effects are often run in conjunction with Norethandrolone.

As with most 19-norandrogens, there should be a concern with the compound interacting with the progesterone receptor and causing some progesterone-like side effects. These are controllable with appropriate use of ancillary compounds however. It should also be noted that the suppression of natural testosterone levels associated with nandrolones will also be experienced with use of this drug.

As with most oral steroids, and nandrolones in general, Norethandrolone is not a "stand alone" compound. It should be stacked with other drugs, preferably one being testosterone, so that its effects can be maximized and the user minimizes the side effects that may appear. Due to the likelihood of water retention because of the aromatization associated with the compound, it is usually reserved for "bulking" phases, however if other drugs are used appropriately it can be utilized while a user is trying to reduce body fat.

As well due to the compound being 17-alpha alkylated users who run it with other oral steroids are putting themselves at risk of causing serious damage to their liver. It is for this reason that it is not recommended that users administer more than one 17-alpha alkylated steroid at once, or for extended periods of time.

Anecdotally, as well as in most research conducted on the drug, the anabolic effect of Norethandrolone is rather moderate. It has been demonstrated that it has a relatively moderate binding affinity for the androgen receptor. It has also been shown to stop protein catabolism, while also stimulating protein synthesis (2). For the most part, this would account for the anabolic effects of the compound.

One benefit of Norethandrolone being orally active and having no ester is that its metabolites will likely be eliminated by the body of the user much faster than with 19-nortestosterone injectable compounds. This could be of some benefit to those athletes concerned with drug testing. It is also true that any benefits to the user�s joints that could be experienced with nandrolone should also become apparent with Norethandrolone as well. There is nothing to suggest that by it being orally active that this would diminish this effect.


Use/Dosing

Due to the active life of the compound, administering the compound twice per day should be adequate to maintain fairly stable blood concentrations of the compound. As well like most 17-alpha alkylated steroids, Norethandrolone should only be used for limited periods of time because of the risks concerning hepatoxicity. By cycling the drug for four to six weeks, most healthy users should avoid any complications concerning liver health. However, as with most compounds, some users extend these runs. Monitoring liver values while using the compound should be done if this is contemplated, as this will ensure that any problems become apparent before they could cause permanent harm.

Anecdotally, many users have reported seeing good results using 30 to 40 milligrams per day. As usual, many users have experimented with doses much higher with good results as well, however this also comes with increased risks of severe side effects. Caution should be taken.

As for women, some may experiment with Norethandrolone but this is at the risk of virilizing symptoms and even possible infertility (3). However, these will be discussed in greater detail in the Risks/Side Effects section of this profile.

As with most oral steroids, and 19-nortestosterone steroids in general, Norethandrolone should be used in conjunction with other anabolic steroids. Its effects may be beneficial in terms of muscle growth, however users may experience negative side effects due to lack of testosterone if no external testosterone is administered because of the suppressive nature of the compound. This can result in loss of libido and sexual dysfunction, among other things. It is for this reason that it is recommended that at the very least some form of testosterone is used when administering Norethandrolone.


Risks/Side Effects

Norethandrolone, like other forms of nandrolone, is a progestin and is capable of aromatizing. By being a progestin, it is able to attach itself to the progesterone receptors in the body and stimulate them (2). This activity can ultimately lead to such side effects as gynecomastia and water retention. However, these symptoms may also be caused by the aromatizing activity of the compound could also result in these side effects as well. For this reason users would be wary of the potential to need to run ancillary drugs to help combat progesterone-like effects, as well as estrogenic side effects.

In terms of treating progesterone-like side effects, using compounds such as bromcriptine, cabergoline and/or vitamin b6 have all been shown and reported to help lower prolactin levels. The drug letrozole is also effective for use with nandrolone as it will regulate the progesterone and estrogen receptors in the body, therefore preventing some of the negative side effects associated with the compound. Letrozole will also help to prevent and/or treat estrogenic side effects that may appear. Other drugs such as tamoxifen citrate, arimidex, and exemestane would also be of benefit in preventing estrogen related symptoms.

As with nandrolone compounds, Norethandrolone is also quite suppressive in terms of natural testosterone production. For this reason users will want to ensure that they are running some form of exogenous testosterone with their cycle to help combat any sexual dysfunction or loss of libido when using this compound. As always, users should also be careful to run a well planned post-cycle therapy once they have stopped their cycle to ensure their testosterone production is restored as quickly as possible.

In terms of side effects associated with the use of Norethandrolone in women, the drug seemingly is more likely to cause virilizing symptoms than most other nandrolones (other than trenbolone of course). Deepening of the voice, body/facial hair growth, and enlargement of the clitoris, among others, are all possible with use of this drug. As well, there is some research that indicates that there is an increased risk of infertility in women who administer this compound (3). For this reason, it is not recommend that women experiment with Norethandrolone.



References

1. Colton FB. Steroids and "the pill": early steroid research at Searle. Steroids. 1992 Dec;57(12):624-30

2. Brady BM, Anderson RA, Kinniburgh D, Baird DT. Demonstration of progesterone receptor-mediated gonadotrophin suppression in the human male. Clin Endocrinol (Oxf). 2003 Apr;58(4):506-12

3. Reed M. Some antifertility effects of Nilevar (17-alpha-ethyl-19-nortestosterone), a progestational steroid, in the female guinea-pig. J Reprod Fertil. 1966 Dec;12(3):489-99






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