Pharmaceutical Name: Norethandrolone
Chemical structure: 17-alpha-ethyl-19-Nor-4-androstene-3-one,17b-ol
Chemical Formula: C20 H30 O2
Molecular Weight: 302.4558
Melting Point: 130-136 Celsius
Active life: 12-16 hours
Anabolic/Androgenic ratio (Range): 100-200/22-55
Norethandrolone is a moderately anabolic oral 17-alpha alkylated steroid. It
was one of the first oral steroids available in the North America (1). It is a
19-nortestosterone steroid. For this reason its effects are often compared to
those of deca durabolan, however this is a rather simplistic explanation.
Androgenic side effects are much more likely to occur with Norethandrolone
than with most other nandrolones. As well, due to the fact that it is 17-alpha
alkylated it converts to 17 alpha ethyl estradiol, a very active form of
estradiol. This is likely to result in more severe estrogenic side effects for
users in comparison to say nandrolone decanoate. For this reason use of
ancillary compounds to try and prevent estrogen-related side effects are often
run in conjunction with Norethandrolone.
As with most 19-norandrogens, there should be a concern with the compound
interacting with the progesterone receptor and causing some progesterone-like
side effects. These are controllable with appropriate use of ancillary
compounds however. It should also be noted that the suppression of natural
testosterone levels associated with nandrolones will also be experienced with
use of this drug.
As with most oral steroids, and nandrolones in general, Norethandrolone is not
a "stand alone" compound. It should be stacked with other drugs, preferably
one being testosterone, so that its effects can be maximized and the user
minimizes the side effects that may appear. Due to the likelihood of water
retention because of the aromatization associated with the compound, it is
usually reserved for "bulking" phases, however if other drugs are used
appropriately it can be utilized while a user is trying to reduce body fat.
As well due to the compound being 17-alpha alkylated users who run it with
other oral steroids are putting themselves at risk of causing serious damage
to their liver. It is for this reason that it is not recommended that users
administer more than one 17-alpha alkylated steroid at once, or for extended
periods of time.
Anecdotally, as well as in most research conducted on the drug, the anabolic
effect of Norethandrolone is rather moderate. It has been demonstrated that it
has a relatively moderate binding affinity for the androgen receptor. It has
also been shown to stop protein catabolism, while also stimulating protein
synthesis (2). For the most part, this would account for the anabolic effects
of the compound.
One benefit of Norethandrolone being orally active and having no ester is that
its metabolites will likely be eliminated by the body of the user much faster
than with 19-nortestosterone injectable compounds. This could be of some
benefit to those athletes concerned with drug testing. It is also true that
any benefits to the user�s joints that could be experienced with nandrolone
should also become apparent with Norethandrolone as well. There is nothing to
suggest that by it being orally active that this would diminish this effect.
Due to the active life of the compound, administering the compound twice per
day should be adequate to maintain fairly stable blood concentrations of the
compound. As well like most 17-alpha alkylated steroids, Norethandrolone
should only be used for limited periods of time because of the risks
concerning hepatoxicity. By cycling the drug for four to six weeks, most
healthy users should avoid any complications concerning liver health. However,
as with most compounds, some users extend these runs. Monitoring liver values
while using the compound should be done if this is contemplated, as this will
ensure that any problems become apparent before they could cause permanent
Anecdotally, many users have reported seeing good results using 30 to 40
milligrams per day. As usual, many users have experimented with doses much
higher with good results as well, however this also comes with increased risks
of severe side effects. Caution should be taken.
As for women, some may experiment with Norethandrolone but this is at the risk
of virilizing symptoms and even possible infertility (3). However, these will
be discussed in greater detail in the Risks/Side Effects section of this
As with most oral steroids, and 19-nortestosterone steroids in general,
Norethandrolone should be used in conjunction with other anabolic steroids.
Its effects may be beneficial in terms of muscle growth, however users may
experience negative side effects due to lack of testosterone if no external
testosterone is administered because of the suppressive nature of the
compound. This can result in loss of libido and sexual dysfunction, among
other things. It is for this reason that it is recommended that at the very
least some form of testosterone is used when administering Norethandrolone.
Norethandrolone, like other forms of nandrolone, is a progestin and is capable
of aromatizing. By being a progestin, it is able to attach itself to the
progesterone receptors in the body and stimulate them (2). This activity can
ultimately lead to such side effects as gynecomastia and water retention.
However, these symptoms may also be caused by the aromatizing activity of the
compound could also result in these side effects as well. For this reason
users would be wary of the potential to need to run ancillary drugs to help
combat progesterone-like effects, as well as estrogenic side effects.
In terms of treating progesterone-like side effects, using compounds such as
bromcriptine, cabergoline and/or vitamin b6 have all been shown and reported
to help lower prolactin levels. The drug letrozole is also effective for use
with nandrolone as it will regulate the progesterone and estrogen receptors in
the body, therefore preventing some of the negative side effects associated
with the compound. Letrozole will also help to prevent and/or treat estrogenic
side effects that may appear. Other drugs such as tamoxifen citrate, arimidex,
and exemestane would also be of benefit in preventing estrogen related
As with nandrolone compounds, Norethandrolone is also quite suppressive in
terms of natural testosterone production. For this reason users will want to
ensure that they are running some form of exogenous testosterone with their
cycle to help combat any sexual dysfunction or loss of libido when using this
compound. As always, users should also be careful to run a well planned
post-cycle therapy once they have stopped their cycle to ensure their
testosterone production is restored as quickly as possible.
In terms of side effects associated with the use of Norethandrolone in women,
the drug seemingly is more likely to cause virilizing symptoms than most other
nandrolones (other than trenbolone of course). Deepening of the voice,
body/facial hair growth, and enlargement of the clitoris, among others, are
all possible with use of this drug. As well, there is some research that
indicates that there is an increased risk of infertility in women who
administer this compound (3). For this reason, it is not recommend that women
experiment with Norethandrolone.
1. Colton FB. Steroids and "the pill": early steroid research
at Searle. Steroids. 1992 Dec;57(12):624-30
2. Brady BM, Anderson RA, Kinniburgh D, Baird DT. Demonstration of
progesterone receptor-mediated gonadotrophin suppression in the human male.
Clin Endocrinol (Oxf). 2003 Apr;58(4):506-12
3. Reed M. Some antifertility effects of Nilevar
(17-alpha-ethyl-19-nortestosterone), a progestational steroid, in the female
guinea-pig. J Reprod Fertil. 1966 Dec;12(3):489-99
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